解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Polymeric semiconductors are materials where unique optical and electronic properties often originate from a tailored chemical structure. This allows for synthesizing conjugated macromolecules with ad hoc functionalities for organic electronics. In photovoltaics, donor-acceptor co-polymers, with moieties of different ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1967
更新日期:2012-07-24 00:00:00
abstract::A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1953
更新日期:2012-07-17 00:00:00
abstract::Phospholipase C is a key enzyme in phosphoinositide turnover. Although its functions have been extensively studied at the cellular level, many questions remain concerning its functions at the organ and individual animal levels. Here we demonstrate that mice lacking phospholipase Cδ1 develop granulocytosis associated w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1960
更新日期:2012-07-17 00:00:00
abstract::The high photon flux and femtosecond pulse duration of hard X-ray free-electron lasers have spurred a large variety of novel and fascinating experiments in physical, chemical and biological sciences. Many of these experiments depend fundamentally on a clean, well-defined wavefront. Here we explore the wavefront proper...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1950
更新日期:2012-07-10 00:00:00
abstract::The recent discovery of high-temperature superconductivity in iron-based compounds has attracted much attention. How to further increase the superconducting transition temperature (T(c)) and how to understand the superconductivity mechanism are two prominent issues facing the current study of iron-based superconductor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1946
更新日期:2012-07-03 00:00:00
abstract::Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in poll...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1941
更新日期:2012-07-03 00:00:00
abstract::In LaAlO(3)/SrTiO(3) heterointerfaces, charge carriers migrate from the LaAlO(3) to the interface in an electronic reconstruction. Magnetism has been observed in LaAlO(3)/SrTiO(3), but its relationship to the interface conductivity is unknown. Here we show that reconstruction is necessary, but not sufficient, for the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1931
更新日期:2012-06-26 00:00:00
abstract::Nanocrystal quantum dots are attractive materials for applications as nanoscale light sources. One impediment to these applications is fluctuations of single-dot emission intensity, known as blinking. Recent progress in colloidal synthesis has produced nonblinking nanocrystals; however, the physics underlying blinking...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1916
更新日期:2012-06-19 00:00:00
abstract::Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1887
更新日期:2012-06-12 00:00:00
abstract::In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1892
更新日期:2012-06-06 00:00:00
abstract::Inbreeding typically reduces fitness. Related partners may fail to reproduce and any inbred offspring may die early or fail to reproduce themselves. Here we show that inbreeding causes early death in the zebra finch Taeniopygia guttata, and among inbred individuals of the same inbreeding coefficient (F), those that di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1870
更新日期:2012-05-29 00:00:00
abstract::The magnetostructural coupling between the structural and the magnetic transition has a crucial role in magnetoresponsive effects in a martensitic-transition system. A combination of various magnetoresponsive effects based on this coupling may facilitate the multifunctional applications of a host material. Here we dem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1868
更新日期:2012-05-29 00:00:00
abstract::It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1854
更新日期:2012-05-22 00:00:00
abstract::The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1837
更新日期:2012-05-15 00:00:00
abstract::Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1820
更新日期:2012-05-08 00:00:00
abstract::Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1803
更新日期:2012-05-01 00:00:00
abstract::According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1814
更新日期:2012-05-01 00:00:00
abstract::One of the best performing semiconducting polymers used in bulk heterojunction devices is PCDTBT, a polycarbazole derivative with solar-conversion efficiencies as high as 7.2%. Here we report the formation of bilayer ordering in PCDTBT, and postulate that this structural motif is a direct consequence of the polymer's ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1790
更新日期:2012-04-24 00:00:00
abstract::Self-assembly of large multi-component systems is a common strategy for the bottom-up construction of discrete, well-defined, nanoscopic-sized cages. Icosahedral or pseudospherical viral capsids, built up from hundreds of identical proteins, constitute typical examples of the complexity attained by biological self-ass...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1793
更新日期:2012-04-17 00:00:00
abstract::Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1764
更新日期:2012-04-10 00:00:00
abstract::The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However, the precise mechanism of pathological cleavage of the TAR DNA-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1766
更新日期:2012-04-03 00:00:00
abstract::A topological insulator is the state of quantum matter possessing gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the proper...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1771
更新日期:2012-03-27 00:00:00
abstract::Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1753
更新日期:2012-03-20 00:00:00
abstract::The same odorant can induce attractive or repulsive responses depending on its concentration in various animals including humans. However, little is understood about the neuronal basis of this behavioural phenomenon. Here we show that Caenorhabditis elegans avoids high concentrations of odorants that are attractive at...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1750
更新日期:2012-03-13 00:00:00
abstract::Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1711
更新日期:2012-03-06 00:00:00
abstract::The nitrogen-vacancy (NV) centre in diamond is a promising candidate for a solid-state qubit. However, its charge state is known to be unstable, discharging from the qubit state NV(-) into the neutral state NV(0) under various circumstances. Here we demonstrate that the charge state can be controlled by an electrolyti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1729
更新日期:2012-03-06 00:00:00
abstract::Large single-crystal graphene is highly desired and important for the applications of graphene in electronics, as grain boundaries between graphene grains markedly degrade its quality and properties. Here we report the growth of millimetre-sized hexagonal single-crystal graphene and graphene films joined from such gra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1702
更新日期:2012-02-28 00:00:00
abstract::One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1710
更新日期:2012-02-28 00:00:00
abstract::HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1681
更新日期:2012-02-21 00:00:00
abstract::The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1683
更新日期:2012-02-21 00:00:00
abstract::Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circuits is a challenge. Here we demonstrate that a significant reduction in the use of field-effect transistors ca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1682
更新日期:2012-02-14 00:00:00
abstract::Light trapping across a wide band of frequencies is important for applications such as solar cells and photodetectors. Here, we demonstrate a new approach to light management by forming whispering-gallery resonant modes inside a spherical nanoshell structure. The geometry of the structure gives rise to a low quality-f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1664
更新日期:2012-02-07 00:00:00
abstract::Porous coordination polymers are well known for their easily tailored framework structures and corresponding properties. Although systematic modulations of pore sizes of binary prototypes have gained great success, simultaneous adjustment of both pore size and shape of ternary prototypes remains unexplored, owing to t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1654
更新日期:2012-01-24 00:00:00
abstract::Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1634
更新日期:2012-01-17 00:00:00
abstract::The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1636
更新日期:2012-01-10 00:00:00
abstract::Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent prop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1612
更新日期:2012-01-03 00:00:00
abstract::Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2041
更新日期:2012-01-01 00:00:00
abstract::Understanding lithospheric plate motions is of paramount importance to geodynamicists. Much effort is going into kinematic reconstructions featuring progressively finer temporal resolution. However, the challenge of precisely identifying ocean-floor magnetic lineations, and uncertainties in geomagnetic reversal timesc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2051
更新日期:2012-01-01 00:00:00
abstract::Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2177
更新日期:2012-01-01 00:00:00
abstract::Tyrosine sulfation, a well-characterized post-translation modification in eukaryotes, has not previously been reported in prokaryotes. Here, we demonstrate that the RaxST protein from the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae, is a tyrosine sulfotransferase. We used a newly developed sulfotransferase ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2157
更新日期:2012-01-01 00:00:00